KATHRIN DREUSICKE BOOKS
Alle folgenden Studien haben die Wirksamkeit von Vitamin-D-Supplements gegen das Coronavirus untersucht:
Basha et al., Clinical Epidemiology and Global Health, doi:10.1016/j.cegh.2020.10.005 (Review) (Peer Reviewed) Is the shielding effect of cholecalciferol in SARS CoV-2 infection dependable? An evidence based unravelingReview of vitamin D for COVID-19, concluding that the available evidence is very suggestive of protective and preventive effect of vitamin D. Authors note that strict lockdown (longer time indoors and home quarantine) may increase the r..
Ling et el., (Preprint)
Vitamin D Treatment Is Associated with Reduced Risk of Mortality in Patients with COVID-19: A Cross-Sectional Multi-Centre Observational StudyRetrospective 986 hospitalized patients in the UK, finding vitamin D treatment was associated with a reduced risk of mortality, regardless of baseline vitamin D status. Vitamin D status (replete/insufficient/deficient) was not associate..
Annweiler et al., The Journal of Steroid Biochemistry and Molecular Biology, doi:10.1016/j.jsbmb.2020.105771 (Peer Reviewed)
Vitamin D and survival in COVID-19 patients: A quasi-experimental studyVitamin D3 supplementation during or just before COVID-19 was associated with 68% lower mortality and less severe COVID-19 in frail elderly. Retrospective 66 French nursing home residents, mean age 87.7, 9 control patients, and 57 that r..
Maghbooli et al., PLOS One, doi:10.1371/journal.pone.0239799 (Peer Reviewed)
Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infectionRetrospective 235 hospitalized patients showing a significant association between vitamin D sufficiency and reduction in clinical severity. For patients over 40, mortality was 9.7% with 25(OH)D levels >30ng/mL, versus 20% for <30ng/mL. ..
Kaufman et al., PLOS One, doi:10.1371/journal.pone.0239252 (Peer Reviewed)
SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levelsAnalysis of 191,779 patients in the US finding COVID-19 positivity strongly and inversely associated with circulating 25(OH)D levels. The relationship persists across latitudes, races/ethnicities, gender, and age ranges. COVID-19 adjuste..
Radujkovic et al., Nutrients 2020, 12:9, 2757, doi:10.3390/nu12092757 (Peer Reviewed)
Vitamin D Deficiency and Outcome of COVID-19 PatientsObservational study 185 patients in Germany shows an association between vitamin D status and severity and mortality. Adjusted hazard ratio of vitamin D sufficiency for combined mechanical ventilation and death was HR 0.16, p < 0.001, and..
Israel et al., medRxiv, doi:https://www.medrxiv.org/content/10.1101/2020.09.04.20188268v1 (Peer Reviewed)The link between vitamin D deficiency and Covid-19 in a large populationLarge observational population study showing a strong association between vitamin D deficiency and COVID-19.
Castillo et al., Journal of Steroid Biochemistry and Molecular Biology, 203, October 2020, doi:10.1016/j.jsbmb.2020.105751 (Peer Reviewed)
Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical studyRCT on calcifediol (25-hydroxyvitamin D) treatment for hospitalized COVID-19 patients showing significantly reduced intensive care unit admissions. All patients received standard care including HCQ+AZ. Significant..
Carpagnano et al., J. Endocrinol. Invest., 2020, Aug 9, 1-7, doi:10.1007/s40618-020-01370-x (Peer Reviewed)
Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19Retrospective study 42 patients with acute respiratory failure, 81% with low vitamin D levels. After 10 days, patients with severe vitamin D deficiency had a 50% probability of dying, while those with vitamin D ≥ 10 ng/mL had a 5% mortal..
Merzon et al., The FEBS Journal, doi:doi.org/10.1111/febs.15495 (Peer Reviewed)
Low plasma 25(OH) vitamin D level is associated with increased risk of COVID‐19 infection: an Israeli population‐based studyAnalysis of 7,807 patients finding that low vitamin D levels are correlated with increased risk of cases and hospitalization. Adjusted odds ratio OR for sufficient vitamin D level for cases 0.69, p < 0.001, and for hospitalization 0.51, p..
Jolliffe et al., medRxiv, doi:10.1101/2020.07.14.20152728 (Peer Reviewed) (meta analysis)Vitamin D supplementation to prevent acute respiratory infections: systematic review and meta-analysis of aggregate data from randomised controlled trialsMeta analysis of 40 RCTs showing that vitamin D supplementation is safe and reduced risk of acute respiratory infections, odds ratio OR 0.89 [0.81-0.98].
Faul et al., Irish Medical Journal, 113:5, 84. (Peer Reviewed)
Vitamin D Deficiency and ARDS after SARS-CoV-2 InfectionAnalysis of 33 hospitalized COVID-19 patients with respiratory failure requiring FiO2 greater than 0.4. Intubation hazard ratio for vitamin D sufficiency HR 0.31, p = 0.03.
Panagiotou et al., medRxiv, doi:10.1101/2020.06.21.20136903 (Peer Reviewed)
Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalised with COVID-19 are associated with greater disease severity: results of a local audit of practiceRetrospective analysis 134 hospitalized patients. 19% of ICU patients had 25(OH)D levels > 50 nmol/L vs. 39.1% of non-ICU patients, p=0.02
Mok et al., bioRxiv, doi:10.1101/2020.06.21.162396 (Preprint)Calcitriol, the active form of vitamin D, is a promising candidate for COVID-19 prophylaxisIn Vitro study showing that the active form of Vitamin D, calcitriol, exhibits significant potent activity against SARS-CoV-2.
Tan et al., Nutrition, doi:10.1016/j.nut.2020.111017 (Peer Reviewed)
A cohort study to evaluate the effect of combination Vitamin D, Magnesium and Vitamin B12 (DMB) on progression to severe outcome in older COVID-19 patientsObservational study of 43 patients >= 50 years old, with 17 patients receiving vitamin D, magnesium, and vitamin B12 (DMB); and 26 control patients, showing a significantly lower need for oxygen therapy and ICU admission with treatment. ..
De Smet et al., medRxiv, doi:10.1101/2020.05.01.20079376 (Preprint)
Vitamin D deficiency as risk factor for severe COVID-19: a convergence of two pandemicsRetrospective 186 hospitalized patients in Belguim, showing that more than 40% of the adult population is vitamin D deficient, and that vitamin D deficiency is correlated with the risk for hospitalization for COVID-19 pneumonia and predis..
Lau et al., medRxiv, doi:10.1101/2020.04.24.20075838 (Preprint)
Vitamin D Insufficiency is Prevalent in Severe COVID-19Analysis of 20 hospitalized COVID-19 patients, 13 requiring ICU admission. 84.6% of the ICU patients had low vitamin D levels versus 57.1% of the non-ICU patients.
Martineau et al., BMJ 2017, 356, doi:10.1136/bmj.i6583 (Peer Reviewed) (meta analysis)
Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant dataMeta analysis of 25 RCTs showing vitamin D supplementation was safe and it protected against acute respiratory tract infection overall. Patients who were very vitamin D deficient and those not receiving bolus doses experienced the most be..